RAF Typhoon FGR4s have operated alongside France's air force in a combined operation targeting an underground arms cache in Syrian territory operated by the Islamic State group (IS), per a report from the UK Ministry of Defence.
The location, identified by surveillance, was thought to be housing weapons and explosive materials, the announcement noted, and was located in mountainous terrain just north of the historic site of Palmyra in central Syria.
"Our aircraft utilized laser-guided Paveway IV weapons to target a series of entry passages providing entry to the site... early reports are that the strike was effective," the MoD said.
There was no sign of any harm to civilians in the operation late on Saturday and every plane involved returned safely, the ministry further stated.
The British jets were backed up by a Voyager refuelling tanker.
IS - referred to as ISIS - enforced extremist governance over significant areas in Syria and Iraq prior to its 2019 collapse.
"This action demonstrates our UK leadership, and commitment to operate in unison with our partners, to eradicate any revival of the terrorist group and their violent and radical beliefs in the region," the British Defence Secretary the minister said.
UK warplanes have conducted surveillance missions over Syrian airspace to "forestall any efforts to regroup" of the group subsequent to its routing at the climactic battle in Baghuz in the year 2019, the authorities noted.
"I extend gratitude to every member of the UK armed forces who took part in this mission for their professionalism and their courage," he said. "They were part of a great many British troops stationed over the festive period. This mission, to remove militants who threaten our security, shows how UK forces are ready to step up, all year round, protecting the UK domestically and influential overseas."
In December, the United States armed forces executed what it called a "major assault" targeting Islamic State objectives in the country, after an assault claimed the lives of two American soldiers and a local interpreter in Palmyra.
The UN says Daesh still has an estimated 5,000 to 7,000 combatants in both countries.